Denis Dermadi, PhD

Photoshop

An example of network analysis. For more finished work look at publications.An example of network analysis. For more finished work look at publications.

Photoshop, cover image for my PhD dissertation 

Photoshop

This figure was drawn in Photoshop for purposes of illustration in my PhD dissertation. 
Stem cells are at the bottom of the crypt: green, proliferative cells are found in the lower third of the crypt: red, and differentiated cells are in the remaining two thirds of the crypt: blue. Yellow cells are goblet cells. The cells at the top of the crypt undergo apoptosis and shredded.

This figure was drawn in Photoshop for purposes of illustration in my PhD dissertation. 
Abnormalities in APC and mismatch repair genes are early changes in normal epithelium leading to an early adenoma. Increase of epigenetic abnormalities is postulated to be one of the first changes in colon cancer development. additional mutations are needed for more advanced stages of colon cancer.

This figure was drawn in Photoshop for purposes of illustration in my PhD dissertation. 
After laborious wet lab, and calculation of relative protein expressions, more interesting data analysis is done: identification of differentially expressed proteins, advanced analyses e.g. hierarchical clustering and principal component analysis and systems biology - network analysis.

This figure was drawn in Photoshop for purposes of illustration in my PhD dissertation. 
Western diet shifts energy metabolism towards fatty acid oxidation (FAO) and fatty acids become primary source of energy, which leads to upregulated oxidative phosphorylation (OXPHOS) and results in increased levels of reactive oxygen species (ROS). Increased levels of ROS damage proteins and DNA. Cellular mechanisms for reduction of ROS toxicity are activated

Work in progress, Adobe Illustrator.